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VHL Mouse anti-Human, Clone: OTI1E1, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA506222S

Catalog No. 50-167-6541


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Description

Description

Von Hippel-Lindau syndrome (VHL) is a domitly inherited familial cancer syndrome predisposing to a variety of maligt and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications

Specifications

VHL
Monoclonal
Unconjugated
VHL
Liquid
VHL
Full length human recombit protein of human VHL produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI1E1
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P40337
HRCA1, RCA1, VHL1, pVHL
Mouse
IgG2b
30 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7428
Documents
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