VHL Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 165381AP
DescriptionVon Hippel-Lindau syndrome (VHL) is a domitly inherited familial cancer syndrome predisposing to a variety of maligt and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|P40337, P40338, Q64259|
|HRCA1, Protein G7, pVHL, RCA1, VHL, VHL1, Von Hippe-Lindau|
|22346, 24874, 7428|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)|
|VHL Fusion Protein Ag9843|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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