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Tocris Bioscience™ Vialinin A Available on GSA/VA Contract for Federal Government customers only.

Inhibitor of USP4 and USP5/IsoT

Manufacturer:  Tocris Bioscience™ 4988/1

Catalog No. 49-881-R


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Description

Description

Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.

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