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VISTA Mouse anti-Human, FITC, Clone: B7H5DS8, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 11108842

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Catalog No. 11-108-842

Please call customer service for current pricing. 1-800-766-7000


Description

Description

Description: This B7H5DS8 monoclonal antibody recognizes human VISTA, also known as B7-H5 or PD-1H. This clone has been tested and shown not to cross-react with human B7-H4, B7-H6 and B7-H7. This B7H5DS8 antibody will work in flow cytometry only on live and not paraformaldehyde-fixed cells. Applications Reported: This B7H5DS8 antibody has been reported for use in flow cytometric analysis. Applications Tested: This B7H5DS8 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-H1, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans VISTA is expressed predomitly on hematopoietic cells with the highest densities on CD11b+ myeloid cells, and somewhat lower levels on CD4 and CD8 T cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. Mice deficient in VISTA are viable and have elevated frequencies of activated T cells but do not spontaneously develop autoimmune disorders.
Specifications

Specifications

VISTA
Monoclonal
5 μl/Test
PBS with 0.1μL/Test gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q9H7M9
B7-H5, PD-H1, Gi24, Dies1, SISP1, C10orf54, PD-1H
Mouse
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
64115
Flow Cytometry
B7H5DS8
FITC
VSIR
Liquid
VSIR
VISTA-Fc protein
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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