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VISTA Rat anti-Mouse, PE, Clone: MIH64, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 566270

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Catalog No. BDB566270


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Description

Description

The MIH64 monoclonal antibody specifically binds to V-domain Ig suppressor of T cell activation (VISTA) which is also known as, Differentiation of ESCs 1 (Dies1). VISTA is a type I transmembrane glycoprotein that belongs to the Ig superfamily. VISTA has homology to the B7 family ligand, PD-L1 (CD274), and is likewise known as PD-1H. VISTA is expressed on naοve and activated T cells, natural killer (NK) cells, macrophages, dendritic cells, and neutrophils. VISTA functions as an inhibitory ligand. It can serve as a negative immune-checkpoint protein that suppresses T cell cytokine production and proliferation. It is also involved in regulating stem cell differentiation.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
Specifications

Specifications

VISTA
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Vista, PD-1H, Dies1
Mouse
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
RUO
Primary
Murine
MIH64
PE
Affinity Purified
Rat
Rat IgG2a, κ
25μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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