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VSIG4 Monoclonal Antibody (JAV4), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$146.65 - $153.00
Specifications
| Antigen | VSIG4 |
|---|---|
| Clone | JAV4 |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
17-575-741
|
Invitrogen
17575741 |
25 Tests |
Each
for $146.65
Save 4% Reg : |
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|
17-575-742
|
Invitrogen
17575742 |
100 Tests |
Each for $153.00
|
|
|||||
Description
Description: This JAV4 monoclonal antibody recognizes human V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig. There are two variants of human VSIG4 that result from alternative splicing. Isoform 1 is longer and more prevalent than isoform 2, and this JAV4 antibody recognizes both. VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins. It contains one complete V-type Ig domain and one truncated C-type Ig domain. VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages. It has been shown to bind complement components C3b and iC3b. This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens. VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation. Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion. Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4. The JAV4 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized. This antibody does not cross-react with mouse or rat VSIG4. Applications Reported: This JAV4 antibody has been reported for use in flow cytometric analysis.
VSIG4 Monoclonal antibody specifically detects VSIG4 in Human samples. It is validated for Flow Cytometry.Specifications
| VSIG4 | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
| A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG | |
| VSIG4 | |
| IgG2a κ | |
| Affinity chromatography | |
| Antibody |
| JAV4 | |
| Flow Cytometry | |
| APC | |
| Mouse | |
| Human | |
| Q9Y279 | |
| 11326 | |
| Fc-Protein and CHO cells | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! | |
| VSIG4 |
For Research Use Only.
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