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Tocris Bioscience™ VU 0424465

Potent mGlu5 positive allosteric modulator and agonist; binds allosteric site with high affinity

$194.30 - $818.00

Specifications

CAS 1428630-85-6
Chemical Name or Material 5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
Molecular Formula C19H19FN2O2
Purity 98%
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Products 2
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Catalog Number Mfr. No. Quantity Price Quantity & Availability  
68-951-0
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Tocris Bioscience™
6895/10
10 mg
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68-955-0
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Tocris Bioscience™
6895/50
50 mg
Each for $818.00
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Description

Description

  • Potent mGlu5 positive allosteric modulator (EC50 = 1.5 nM) and agonist (EC50 = 171 nM; maximum effect is 65% that of glutamate).
  • Binds allosteric site with high affinity (Ki = 11.8 nM).
  • Increases maximum response to glutamate by 30%.
  • Exhibits bias towards signaling via IP1 and ERK1/2 over iCa2+ in HEK293 and neuronal cells, and activates Gs in HEK 293 cells.
  • Induces epileptiform activity in CA3 hippocampal neurons in vitro and convulsions in vivo.
Specifications

Specifications

1428630-85-6
5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
C19H19FN2O2
98%
SDS
Product Certifications
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