- Potent and selective positive allosteric modulator of M4 receptor; potentiates activity of ACh at M4 (EC50 values are 26.6 and 78.8 nM at rat and human M4 receptors, respectively).
- Exhibits selectivity for M4 over human and rat M1-3, 5, and a panel of 200 other pharmacological targets.
- Displays efficacy in a rat model of antipsychotic activity.
- Orally bioavailable and brain penetrant.
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