VWA5A Mouse anti-Human, Clone: OTI3D6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525211
DescriptionVWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of maligt activity in cells with ectopic expression of VWA5A.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|BCSC-1, BCSC1, LOH11CR2A, breast cancer suppressor candidate 1, loss of heterozygosity 11 chromosomal region 2 gene A protein, loss of heterozygosity, 11, chromosomal region 2, gene A, ortholog of mouse AW551984, von Willebrand factor A domain-containing protein 5A|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of VWA5A produced in HEK293T cell|
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