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VWA5A Mouse anti-Human, Clone: OTI3D6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525211

Catalog No. PIMA525211


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Description

Description

VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of maligt activity in cells with ectopic expression of VWA5A.
Specifications

Specifications

VWA5A
Monoclonal
0.69 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O00534
BCSC-1, BCSC1, LOH11CR2A, breast cancer suppressor candidate 1, loss of heterozygosity 11 chromosomal region 2 gene A protein, loss of heterozygosity, 11, chromosomal region 2, gene A, ortholog of mouse AW551984, von Willebrand factor A domain-containing protein 5A
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
4013
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3D6
Unconjugated
VWA5A
Liquid
VWA5A
Full length human recombit protein of VWA5A produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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