VWF Monoclonal Antibody (OTI8G8), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA803608

Catalog No. 50-167-9846

Description

Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein, which binds to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. It is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize/ store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or maligt. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence.

Specifications

• Antigen: VWF
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P04275
• Gene Symbols: VWF
• Immunogen: Human recombit protein fragment corresponding to amino acids 764-1263 of human VWF produced in SF9 cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI8G8
• Conjugate: Unconjugated
• Gene: VWF
• Gene Alias: F8VWF, VWD
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7450
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid