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WASH2P Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549182

Catalog No. PA549182


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Description

Description

Predicted to react with bovine, mouse and rat based on sequence homology.

Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Its assembly in the WASH core complex seems to inhibit its NPF activity and via FAM21 is required for its membrane targeting. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T cells involved in endosome-to- membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to- membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T cell activation. Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
Specifications

Specifications

WASH2P
Polyclonal
PBS with 0.09% sodium azide
Q6VEQ5
WAS protein family homolog 2, CXYorf1-like protein on chromosome 2, Protein FAM39B, WASH2P, FAM39B
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
375260
Western Blot
Unconjugated
WASH2P
Liquid
WASH2P
KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human WASH2P.
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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