DescriptionWD repeat-containing protein 5 (WDR5) antagonist (Kd = 450nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.
- Chemical Name: 3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester
- Formula: C21H25N3O4
- CAS Number: 890190-22-4
- Solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
- Purity: >99
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