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WIBG Mouse anti-Human, Clone: OTI9C7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526797

Catalog No. PIMA526797


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Description

Description

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Specifications

Specifications

WIBG
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9BRP8
PYM; partner of Y14 and mago; protein wibg homolog
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
84305
Immunohistochemistry (Paraffin)
OTI9C7
Unconjugated
PYM1
Liquid
PYM1
Full length human recombit protein of WIBG produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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