Tocris™ Wnt-C59

Highly potent PORCN inhibitor

Manufacturer: Tocris™ 5148/10

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Catalog No. 51-481-0

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For Research Use Only


    Product Type Wnt-C59
    Inhibitors Wnt-C59
    Purity >99
    Molecular Weight 379.45
    Quantity 10mg

    Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.

    • Chemical Name: 4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide
    • Formula: C25H21N3O
    • CAS Number: 1243243-89-1
    • Solubility: Soluble to 20mM in DMSO and to 20mM in ethanol
    • Purity: >99

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