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WTAP Mouse anti-Human, Clone: OTI12G7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526972

Catalog No. PIMA526972


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Description

Description

Wilms ft. tumor (WT) is an embryonal maligcy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms ft. tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3 ft. UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
Specifications

Specifications

WTAP
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q15007
PNAS-132, WT1-associated protein, Wilms′ tumour 1-associating protein, female-lethal(2)D homolog, hFL(2)D, pre-mRNA-splicing regulator WTAP, putative pre-mRNA splicing regulator female-lethal(2D), wilms tumor 1-associating protein
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9589
Immunohistochemistry (Paraffin), Western Blot
OTI12G7
Unconjugated
WTAP
Liquid
WTAP
Human recombit protein fragment corresponding to amino acids 2-106 of WTAP produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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