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WTIP Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548292

Catalog No. PA548292


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Description

Description

Predicted to react with mouse based on sequence homology.

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.
Specifications

Specifications

WTIP
Polyclonal
Unconjugated
WTIP
Liquid
WTIP
KLH conjugated synthetic peptide between 243-271 amino acids of human WTIP.
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
A6NIX2
Wilms tumor protein 1-interacting protein, WT1-interacting protein, WTIP
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
126374
Documents
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