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WWTR1 Monoclonal Antibody (OTI1A12), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Supplier: OriGene TA503438
Description
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.Specifications
WWTR1 | |
Monoclonal | |
0.61 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
Q9EPK5, Q9GZV5 | |
WWTR1 | |
Full length human recombit protein of human WWTR1 produced in HEK293 cell. | |
100 μL | |
Primary | |
Canine, Human, Mouse | |
Antibody | |
IgG2a |
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot | |
OTI1A12 | |
Unconjugated | |
WWTR1 | |
TAZ | |
Mouse | |
Affinity Chromatography | |
RUO | |
25937, 609743, 97064 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
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