Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
WYE 687 dihydrochloride, Tocris Bioscience™
Click to view available options
Quantity:
10 mg
50 mg
Description
Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-Kα (∽100-fold) and PI 3-Kγ (∽500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.
Specifications
Quantity | 50 mg |
Formula Weight | 601.53 |
Percent Purity | >98% |
Chemical Name or Material | WYE 687 dihydrochloride |
Safety and Handling
Recommended Storage | Desiccate at Room Temperature |
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction