Potent and selective NUAK1/2 inhibitor (IC50 values are 20 and 100nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.
Chemical Name: N-3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide
CAS Number: 1214265-58-3
Solubility: Soluble to 50mM in 1eq. HCl and to 20mM in DMSO with gentle warming
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