XAB1, Mouse anti-Human, Biotin, Clone: GPN1/2350, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP275783B

Catalog No. NB009207

Description

XAB1 Monoclonal antibody specifically detects XAB1 in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin).

Specifications

• Antigen: XAB1
• Clone: GPN1/2350
• Dilution: ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin
• Format: Conjugated, Purified
• Gene Symbols: GPN1
• Immunogen: Recombinant full-length human XAB1 protein
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Storage Requirements: Store at 4°C in the dark.
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human

• Applications: ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin)
• Conjugate: Biotin
• Formulation: PBS with 0.05% Sodium Azide
• Gene Alias: ATP(GTP)-binding protein, ATPBD1A, GPN-loop GTPase 1, GTPase, MBD2-interacting protein, MBDin, MBDINXPA binding protein 1, XAB1FLJ51176, XPA-binding protein 1
• Host Species: Mouse
• Isotype: IgG1 Kappa
• Quantity: 0.1 mL
• Research Discipline: Signal Transduction
• Primary or Secondary: Primary
• Test Specificity: GPN1 is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating GPN1 in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that GPN1 has possible GTPase activity.