Tocris XL 184
Potent VEGFR inhibitor; also inhibits other RTKs
Manufacturer: Tocris 5422/50
DescriptionPotent VEGFR inhibitor (IC50 = 0.035nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.
- Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
- Formula: C28H24FN3O5
- CAS Number: 849217-68-1
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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