Tocris™ XL 184

Potent VEGFR inhibitor; also inhibits other RTKs

Manufacturer: Tocris™ 5422/10

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Catalog No. 54-221-0

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For Research Use Only


    Product Type XL 184
    Inhibitors XL 184
    Purity >98
    Molecular Weight 501.51
    Quantity 10mg

    Potent VEGFR inhibitor (IC50 = 0.035nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.

    • Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
    • Formula: C28H24FN3O5
    • CAS Number: 849217-68-1
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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