Tocris™ XL 388

Potent and selective mTOR inhibitor; antitumor

Manufacturer: Tocris™ 4893/10

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Catalog No. 48-931-0

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For Research Use Only


    Inhibitors XL 388
    Purity >98
    Molecular Weight 455.5
    Quantity 10mg
    Product Type XL 388

    Potent and selective mTOR inhibitor (IC50 = 9.9nM). Inhibits mTOR activity in an ATP-competitive manner. Exhibits >300-fold selectivity for mTOR over PI 3-K and a range of other kinases. Displays antitumor activity in athymic nude mice implanted with tumor xenografts.

    • Chemical Name: [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
    • Formula: C23H22FN3O4S
    • CAS Number: 1251156-08-7
    • Solubility: Soluble to 50mM in DMSO
    • Purity: >98

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