XPF Monoclonal Antibody (51), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA512060

Catalog No. PIMA512060

Description

MA5-12060 targets XPF in WB applications and shows reactivity with Human samples. The MA5-12060 immunogen is recombinant human XPF protein.

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.

Specifications

• Antigen: XPF
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide, pH 7.4
• Gene Accession No.: Q92889
• Gene Symbols: ERCC4
• Immunogen: Recombinant human XPF protein
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: ChIP Assay, Western Blot
• Clone: 51
• Conjugate: Unconjugated
• Gene: ERCC4
• Gene Alias: AI606920, DNA excision repair protein ERCC-4, DNA repair endonuclease subunit, DNA repair endonuclease XPF, DNA repair protein complementing XP-F cells, ERCC excision repair 4, endonuclease catalytic subunit, ERCC11, ERCC4, Ercc4 protein-like, excision repair cross-complementation group 4, excision repair cross-complementing rodent repair deficiency, complementation group 4, excision-repair, complementing defective, in Chinese hamster, FANCQ, RAD1, RGD1560340, Xeroderma pigmentosum group F-complementing protein, xeroderma pigmentosum, complementation group F, XFEPS, XPF
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2072
• Content And Storage: 4°, C
• Isotype: IgG2b κ