XPF Monoclonal Antibody (OTI3H10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA503324

Catalog No. 50-167-4251

Description

The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3′ of the DNA lesion while the ERCC1 / XPF complex makes the 5′ incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.

Specifications

• Antigen: XPF
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q92889, Q9QZD4
• Gene Symbols: Ercc4
• Immunogen: Full length human recombit protein of human ERCC4 produced in HEK293 cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI3H10
• Conjugate: Unconjugated
• Gene: ERCC4
• Gene Alias: ERCC11, FANCQ, RAD1, XFEPS, XPF
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2072, 304719, 479842, 50505
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid