XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ XRCC1 (X-Ray Repair Cross Complementing Protein 1) Ab-1, Mouse Monoclonal Antibody.

Supplier:  Epredia MS434B1

Catalog No. MS434B1

Description

X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase β through the N-terminal half. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.

Host Species: Mouse

Clone: 33-2-5

Isotype: IgG2b

Species Reactivity: Human and Rat. Others not known.

Epitope: Not determined

Immunogen: Recombinant human XRCC1 protein

Molecular Weight: 85kDa

Positive Control: Ls174T, HT29 or HeLa cells; normal testis

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunoprecipitation (Native verified)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: XRCC1 (X-Ray Repair Cross Complementing Protein1) Ab-1
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 500 μL
• Research Discipline: DNA Repair
• Target Species: Human, Rat
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 33-2-5
• Conjugate: Biotin
• Immunogen: Recombinant human XRCC1 protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated