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XRCC4 Mouse anti-Human, Clone: OTI4H9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524983

Catalog No. PIMA524983


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Description

Description

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
Specifications

Specifications

XRCC4
Monoclonal
1.0 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q13426
DNA repair protein XRCC4, X-ray repair cross-complementing protein 4, X-ray repair, complementing defective, repair in Chinese hamster
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7518
Immunohistochemistry (Paraffin), Western Blot
OTI4H9
Unconjugated
XRCC4
Liquid
XRCC4
Full-length protein expressed in 293T cell transfected with human XRCC4 expression vector
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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