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YAP1 Mouse anti-Human, Mouse, Clone: GT256, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527808

Catalog No. PIMA527808


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Description

Description

Positive Control: HeLa, HepG2 Predicted Reactivity: Rat (96%), Zebrafish (87%), Xenopus laevis (81%), Chicken (84%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

YAP1 (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
Specifications

Specifications

YAP1
Monoclonal
1.68 mg/mL
PBS with no preservative
P46937, P46938
YAP, YAP1, YAP1, YAP2, YAP65, YKI, Yes associated protein 1, Yes-associated protein 1
Mouse
IgG2a
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
10413, 22601
Immunohistochemistry (Paraffin), Western Blot
GT256
Unconjugated
YAP1
Liquid
Yap1
Recombit protein encompassing a sequence within the N-terminus region of human YAP1. The exact sequence is proprietary.
Protein A
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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