Tocris™ Z-Guggulsterone

Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)

Manufacturer: Tocris™ 3570/50

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Catalog No. 35-705-0R

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For Research Use Only


    Product Type Z-Guggulsterone
    Inhibitors Z-Guggulsterone
    Purity >98
    Molecular Weight 312.45
    Quantity 50mg

    Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252nM respectively) and weak androgen receptor agonist (Ki = 315nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

    • Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione
    • Formula: C21H28O2
    • CAS Number: 39025-23-5
    • Solubility: Soluble to 25mM in DMSO and to 10mM in ethanol with gentle warming
    • Purity: >98

  • Description & Specifications

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