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ZAK Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551002

Catalog No. PA551002


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Description

Description

ZAK Polyclonal Antibody detects endogenous levels of ZAK protein.

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at  ft.Ser-28 ft.. {ECO:0000269; PubMed:10924358, ECO:0000269; PubMed:11042189, ECO:0000269; PubMed:11836244, ECO:0000269; PubMed:15172994, ECO:0000269; PubMed:15342622, ECO:0000269; PubMed:15684425, ECO:0000269; PubMed:21224381}.
Specifications

Specifications

ZAK
Polyclonal
Unconjugated
MAP3K20
Liquid
MAP3K20
Synthesized peptide derived from the C-terminal region of human MLTK.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q9NYL2, Q9ESL4
MLTK
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51776, 65964
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