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ZAP70, Mouse anti-Human, Alexa Fluor 532, Clone: ZAP70/528 + 2F3.2, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP247775AF532

Catalog No. NB007347

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ZAP70 Monoclonal antibody specifically detects ZAP70 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence.


ZAP70/528 + 2F3.2
Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Conjugated, Purified
Recombinant full-length human ZAP70 protein (ZAP70/528); Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70 (2F3.2)
Protein A or G purified
Store at 4°C in the dark.
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin)
Alexa Fluor 532
50mM Sodium Borate with 0.05% Sodium Azide
70 kDa zeta-associated protein, EC 2.7.10, EC, SRKFLJ17679, STDFLJ17670, Syk-related tyrosine kinase, tyrosine-protein kinase ZAP-70, TZK, ZAP-70, zeta-chain (TCR) associated protein kinase (70 kD), zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD
0.1 mL
Adaptive Immunity, Cell Biology, Immunology, Phospho Specific, Protein Kinase, Signal Transduction, Tyrosine Kinases
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
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