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ZAP70 Mouse anti-Human, Clone: ZAP70/528 + 2F3.2, Azide and BSA Free, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2477750.1MG
SDSDocumentsProduct Certifications Promotions
DescriptionZAP70 Monoclonal specifically detects ZAP70 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
|Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready|
|70 kDa zeta-associated protein, EC 2.7.10, EC 188.8.131.52, SRKFLJ17679, STDFLJ17670, Syk-related tyrosine kinase, tyrosine-protein kinase ZAP-70, TZK, ZAP-70, zeta-chain (TCR) associated protein kinase (70 kD), zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD|
|Adaptive Immunity, Cell Biology, Immunology, Protein Kinase, Signal Transduction, Tyrosine Kinases|
|Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF|
|ZAP70/528 + 2F3.2|
|PBS with No Preservative|
|Recombinant full-length human ZAP70 protein (ZAP70/528); Recombinant ZAP-70 protein including residues 1-254 and encompassing SH2 domains of human ZAP70 (2F3.2)|
|Protein A or G purified|
|ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.|
|Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.|
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