DREF Mouse anti-Human, Clone: OTI1F7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526035
DescriptionZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|ALTE, DREF, TRAMP, hDREF; Ac-like transposable element; BED-type zinc finger domain-containing protein 1; DNA replication-related element binding factor; dREF homolog; zinc finger BED domain-containing protein 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ZBED1 produced in HEK293T cell|
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