ZCCHC17 Mouse anti-Human, Clone: OTI1F11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527170
DescriptionZinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZCCHC17 (zinc finger, CCHC domain containing 17), also known as PS1D (putative S1 RNA-binding domain protein), Pnn (Pinin)-interacting nucleolar protein or pNO40, is a 241 amino acid protein that associates with both Pinin and the 60S ribosomal subunit. Localizing to nucleolus, ZCCHC17 is ubiquitously expressed and has been suggested to play a role in ribosome maturation and biogenesis. ZCCHC17 contains one CCHC-type zinc finger, a S1 motif domain and exists as two alternatively spliced isoforms that map to human chromosome 1p35.2. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in Stickler syndrome, Parkinson ft.s disease, Gaucher disease and Usher syndrome.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Nucleolar protein of 40 kDa; pNO40; Pnn-interacting nucleolar protein; Putative S1 RNA-binding domain protein; PS1D protein; Zinc finger CCHC domain-containing protein 17; ZCCHC17; PS1D|
|-20° C, Avoid Freeze/Thaw Cycles|
|Full length human recombit protein of ZCCHC17 produced in E.coli|
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