ZCCHC9 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA551178
The antibody detects endogenous levels of total ZCCHC9 protein.Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZCCHC9 (zinc finger, CCHC domain containing 9) is a 271 amino acid protein that contains four CCHC-type zinc finger, suggesting a role in transcriptional regulation. The gene encoding ZCCHC9 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
|Fusion protein of human ZCCHC9|
|Antigen affinity chromatography|
|PBS with 40% glycerol and 0.05% sodium azide; pH 7.4|
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