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ZEB1 Mouse anti-Human, Mouse, Rat, Clone: 3G6, eBioscience™ Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 14974180

Encompass

Catalog No. 14-974-180


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Description

Description

The monoclonal antibody 3G6 recognizes human, mouse, and rat ZEB1. ZEB1, or zinc finger E-box binding homeobox 1, is also known as Transcription Factor 8 (TCF8), Negative Regulator of IL2, and AREB6. ZEB1 acts as a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. ZEB1 also regulates expression of the genes E-cadherin, BCL6, ATP1A1, and RCOR1 through binding to multiple enhancer boxes (E-boxes). ZEB1 promotes epithelial mesenchymal transition (EMT) and invasion of various types of cancers, such as colorectal, breast, pancreatic, lung, and gallbladder. In normal tissues, ZEB1 is expressed in tissues undergoing differentiation such as T cell and skeletal differentiation. Mutations in ZEB1 have been associated with corneal dystrophy. Applications Reported: This 3G6 antibody has been reported for use in western blotting, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This 3G6 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue using high pH antigen retrieval and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

ZEB1 Monoclonal antibody specifically detects ZEB1 in Human, Mouse, Rat samples. It is validated for Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Specifications

Specifications

ZEB1
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P37275, Q62947, Q64318
Mouse
25 μg
Primary
Human, Mouse, Rat
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
3G6
Unconjugated
ZEB1
[delta]EF1; 3110032K11Rik; AREB6; BZP; Delta EF1; delta-crystallin enhancer binding factor 1; deltaEF1; DELTA-EF1; FECD6; MEB1; MGC133261; Negative regulator of IL2; Nil2; NIL2A; NIL-2A; NIL-2-A; NIL-2-A zinc finger protein; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; PPCD3; RP11-472N13.4; Tcf18; Tcf8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); Tw; twirler; ZEB; Zeb1; zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box binding homeobox 1; zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; zinc finger homeodomain enhancer-binding protein
Affinity chromatography
RUO
21417, 25705, 6935
Antibody
IgG2a
Safety and Handling

Safety and Handling

SDS
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