ZFP36 Mouse anti-Human, Clone: OTI1A2, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525406
DescriptionZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Zinc finger protein 36, C3H type, homolog (mouse), G0S24, GOS24, NUP475, RNF162A, TIS11, TTP|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ZFP36 produced in HEK293T cell|
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