ZFYVE21 Mouse anti-Human, Clone: OTI2B12, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA505606
DescriptionZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
|Full length human recombit protein of human ZFYVE21 produced in HEK293T cell.|
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