ZFYVE21 Mouse anti-Human, Clone: OTI2B12, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA505606

Catalog No. 50-167-6052

Description

ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.

Specifications

• Antigen: ZFYVE21
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9BQ24
• Gene Alias: HCVP7TP1, ZF21
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 79038

• Applications: Western Blot
• Clone: OTI2B12
• Conjugate: Unconjugated
• Gene: ZFYVE21
• Format: Liquid
• Gene Symbols: ZFYVE21
• Immunogen: Full length human recombit protein of human ZFYVE21 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human