Zika Virus NS1 Mouse anti-Virus, Clone: A831, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524584
MA5-24584 does not cross react with the following viruses: Dengue 1-4, TBE virus, West Nile virus, Yellow Fever virus, Japanese Encephalitis virus and Chikungunya virus.As a member of the Flaviviridae family, ZIKV has a single positive sense RNA genome, which is initially translated as a single polyprotein which is then cleaved post-transitionally into three structural proteins (C, PrM or M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5)(1). The glycosated NS1 forms a homodimer inside the cells and is necessary for viral replication and late in infection (2). NS1 is also secreted into the extracellular space as a hexameric lipoprotein particle, which assists the virus in immune evasion and pathogenesis by interacting with components from both innate and adaptive immune systems as well as other host factors (1). Reference 1) Song, H.; Qi, J.; Haywood, J.; Shi, Y.; Gao, G.F. (2016). Nat. Struct. Mol. Biol. 23, 456-458. 2) Suthar, M.S., Diamond, M.S. & Gale, M. Jr. (2013). Nat. Rev. Microbiol. 11, 115-128.
|Zika Virus NS1|
|PBS with 0.1% sodium azide; pH 7.2|
|ZIKV NS1; ZIKV-NS1; Zika Nonstructural protein 1; Zika NS1|
|recombit Zika Virus NS1 protien|
|ELISA, Immunocytochemistry, Immunofluorescence|
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