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ZRANB2 Mouse anti-Human, Clone: OTI2E3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527175

Catalog No. PIMA527175


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Description

Description

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5 ft.-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
Specifications

Specifications

ZRANB2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O95218
Zinc finger Ran-binding domain-containing protein 2, Zinc finger protein 265, Zinc finger, splicing, ZRANB2, ZIS, ZNF265
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9406
Immunohistochemistry (Paraffin)
OTI2E3
Unconjugated
ZRANB2
Liquid
ZRANB2
Human recombit protein fragment corresponding to amino acids 95-320 of ZRANB2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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