Tocris Bioscience ZJ 43, Tocris
Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
Manufacturer: Tocris Bioscience 2675/10
DescriptionPotent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (K i values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC 50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.
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|Observed MW: 304.3|
|Soluble to 100mM in DMSO|
Safety and Handling
Recommended Storage : Store at -20°C
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