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Tocris Bioscience™ ZJ 43, Tocris Available on GSA/VA Contract for Federal Government customers only.

Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor

Manufacturer:  Tocris Bioscience™ 2675/10

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Catalog No. 26-751-0

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.

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Description

Description

Potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (K i values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC 50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.

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Specifications

Specifications

N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
C12H20N2O7
10mg
723331-20-2
Observed MW: 304.3
Soluble to 100mM in DMSO
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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