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Tocris Bioscience™ ZJ 43
Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
Supplier: Tocris Bioscience™ 2675/10
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Description
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.Specifications
| N-[[[(1 S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid | |
| 10 mg | |
| Carboxypeptidase Inhibitors | |
| Observed MW: 304.3 |
| 723331-20-2 | |
| Soluble to 100mM in DMSO | |
| C12H20N2O7 | |
| 95% |
Safety and Handling
Recommended Storage : Store at -20°C
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