Tocris ZM 336372
Potent, selective c-Raf inhibitor
Manufacturer: Tocris 1321/10
DescriptionPotent, selective inhibitor of c-Raf in vitro (IC50 = 70nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2µM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50µM). Also available as part of the MAPK Cascade Inhibitor Tocriset.
- Chemical Name: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]benzamide
- Formula: C23H23N3O3
- CAS Number: 208260-29-1
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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