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ZMIZ1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA560936

Catalog No. PIPA560936


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Description

Description

Immunogen sequence: MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFT Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predomitly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
Specifications

Specifications

ZMIZ1
Polyclonal
Unconjugated
ZMIZ1
Liquid
ZMIZ1
Recombit protein corresponding to Human ZMIZ1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9ULJ6
RP11-519K18.1, MIZ, RAI17, TRAFIP10, ZIMP10, hZIMP10; FLJ00092 protein; RP11-519K18.1; retinoic acid induced 17; zinc finger MIZ domain-containing protein 1; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
57178
SDS
Documents
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