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ZNF451 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 252281AP

Catalog No. 50-173-4801


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Description

Description

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in maligt cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of maligt cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
Specifications

Specifications

ZNF451
0.31 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9Y4E5
COASTER, KIAA0576, KIAA1702, zinc finger protein 451, ZNF451
Rabbit
IgG
150 μL
-20°C
Primary
26036
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
ZNF451
Liquid
ZNF451
ZNF451 Fusion Protein Ag18346
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
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