ZNF521 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572984

Catalog No. PIPA572984

Description

The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.

Specifications

• Antigen: ZNF521
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ZNF521
• Gene Alias: ZNF521, Zinc finger protein 521, EHZF, Evi3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 225207, 25925
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Concentration: 1.11 mg/mL
• Formulation: PBS with 30% glycerol and 0.05% sodium azide
• Gene Accession No.: Q6KAS7, Q96K83
• Gene Symbols: Zfp521, ZNF521
• Immunogen: A synthetic peptide made to an internal portion of the human ZNF521 protein (between residues 450-550) [UniProt Q96K83]
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG