Invitrogen™ ZP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530879

Catalog No. PIPA530879

Description

Recommended positive controls: NT2D1, IMR32, U87-MG. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.

Specifications

• Antigen: ZP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Zp2
• Gene Alias: 75-kDa rabbit zona pellucida protein; Processed zona pellucida sperm-binding protein 2; zona pellucida 2 glycoprotein; zona pellucida A protein; zona pellucida glycoprotein 2; zona pellucida glycoprotein 2 (sperm receptor); zona pellucida glycoprotein ZP2; zona pellucida glycoprotein ZPA; zona pellucida protein A; Zona pellucida sperm-binding protein 2; ZP2; Zp-2; ZPA
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7783
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.89 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q05996
• Gene Symbols: Zp2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 313 of Human ZP2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG