ZRANB2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 248161AP
In WB, a band of ~48 kDa is detected. The immunogen of this antibody is 1-241aa. No other protein can be recognized by this antibody from the sequence BLAST results.Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5 ft.-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|Zinc finger protein 265, Zinc finger, splicing, ZIS, ZIS1, ZIS2, ZNF265, ZRANB2|
|ZRANB2 Fusion Protein Ag20487|
|Antigen Affinity Chromatography|
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