Custom Enzymes and Inhibitors

Tocris™ SynaptoRed C2

Fluorescent dye; stains synaptic vesicles

Tocris™ R 59-022

Diacylglycerol kinase inhibitor; increases PKC activity

Tocris™ Calcein AM

Cell permeable compound; hydrolyzed to become fluorescent in living cells

Tocris™ Boric acid

Widely used in buffers for electrophoresis

R&D Systems Caspase Inhibitor Control Z-FA-FMK

Designed for in vitro use as a cell permeable control for the effects of fluoromethyl-ketone derivatives on caspase activity

Tocris™ Dansyl-NECA

Potent and selective fluorescent adenosine A1 agonist

Tocris™ (±)-SLV 319

Potent and selective CB1 receptor antagonist

Tocris™ C 21

Selective PRMT1 inhibitor

Tocris™ Ro 25-6981 maleate

Subtype-selective NR2B antagonist

Tocris™ IDRA 21

Inhibits AMPA receptor desensitization

Tocris™ (+)-Igmesine hydrochloride

Selective sigma1 ligand; antidepressant

Tocris™ AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

Tocris™ J 147

Neuroprotective and neurotrophic compound; reduces Abeta40 and Abeta42 levels

Tocris™ Urea

Used to solubilize and denature proteins

Tocris™ EC 144

High affinity, potent and selective Hsp90 inhibitor

Tocris™ CHC

MCT inhibitor; decreases glycoloysis

R&D Systems™ Boston Biochem Proteasome Inhibitor Z-Leu-Leu-Leu-CHO (MG-132)

Inhibits NF-kappaB activation. R&D Systems™ Boston Biochem Z-Leu-Leu-Leu-CHO (MG-132) is a proteasome and calpain inhibitor.

Tocris™ AH 7614

Selective FFA4 (GPR120) antagonist

Tocris™ Abacavir hemisulfate

Reverse transcriptase inhibitor; antiretroviral

Tocris™ FR 171113

PAR1 antagonist

Tocris™ Neurodazine

Induces neurogenesis in mature skeletal muscle cells

Tocris™ SC 144 hydrochloride

gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Tocris™ CHR 2797

Aminopeptidase inhibitor

R&D Systems Z-Leu-Leu-Nva-CHO (MG-115)

Reversible, cell-permeable chymotrypsin-like peptidase inhibitor of the 20S proteasome

Tocris™ NPS 2143 hydrochloride

Selective antagonist of the calcium-sensing receptor; orally active calcilytic agent

Tocris™ Gambogic acid

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

Tocris™ ABT 724 trihydrochloride

Potent, selective D4 partial agonist; proerectile

Tocris™ ICI 204,448 hydrochloride

kappa agonist, acts peripherally

Tocris™ VU 0238429

Selective positive allosteric modulator of M5 receptors

Tocris™ PD 98059

MEK inhibitor