Custom Services and Products

Tocris™ CDDO Im

Nrf2 signaling activator

Tocris™ pep2m

Peptide inhibitor of GluR2 subunit binding to NSF. Reduces AMPA currents

Tocris™ R18

Inhibitor of 14.3.3 proteins

R&D Systems VersaClone cDNA, Human Insulin R/CD220 (NP_000199)

The insulin receptor homodimers are activated by insulin and, in adults, mediate an increase in glucose uptake through upregulation of GLUT4 expression

R&D Systems VersaClone cDNA, Human ABCB5 (NP_001157413)

ABC transporters and MDR will likely be important in the therapeutic optimization for cancer patients

Tocris™ GSK 2194069

Potent human fatty acid synthase (hFASN) inhibitor

R&D Systems Human GABA-A R gamma 2 (NP_944493) VersaClone cDNA

gamma-aminobutyric acid (GABA) A receptor, GABRG2, gamma-aminobutyric acid receptor subunit gamma-2

R&D Systems PS-341, 26S Proteasome Inhibitor

A potent, specific, and reversible proteasome inhibitor

Tocris™ TAK 960 hydrochloride

Potent and selective PLK1 inhibitor

R&D Systems VersaClone cDNA, Mouse GPR35 (NP_071715)

GPR53 acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway

R&D Systems Human IL-23 R (AAM44229) VersaClone cDNA

IL-23R; interleukin 23 receptor; interleukin-23 receptor

R&D Systems VersaClone cDNA, Mouse Axl (NP_033491)

AXL is involved in the stimulation of cell proliferation and can mediate cell aggregation by homophilic binding

R&D Systems Mouse VSIG10 (NP_001028483) VersaClone cDNA

V-Set and Immunoglobulin Domain Containing 10

Tocris™ Z-VDVAD-FMK

Irreversible caspase-2 inhibitor

R&D Systems Human SLC6A8 (NP_005620) VersaClone cDNA

Creatine Transporter 1, CCDS1, CHOT1

R&D Systems VersaClone cDNA, Mouse BMPR-II (NP_031587)

BMPR2 is one of the five mammalian type II receptors for the TGF ? superfamily ligands. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling

Tocris™ TC-E 5007

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

R&D Systems VersaClone cDNA, Human VSIG2 (NP_055127)

VSIG2 is a type I transmembrane glycoprotein at contains multiple N-glycosylation sites in the extracellular region and phosphorylation sites in the cytoplasmic tail.

R&D Systems Mouse IL-23 R (NP_653131) VersaClone cDNA

IL-23 receptor; IL-23R; interleukin 23 receptor; interleukin-23 receptor

R&D Systems VersaClone cDNA, Human FGF R3 (NP_000133)

Mutations in FGFR3 may be associated with craniosynostosis and multiple types of skeletal dysplasia. This isoform is known as FGFR3a (IIIc)

R&D Systems Human VSIG10 (NP_061959) VersaClone cDNA

V-Set and Immunoglobulin Domain Containing 10

Tocris™ Fluoxetine - d5 hydrochloride

Deuterated fluoxetine (Cat. No. 0927)

R&D Systems VersaClone cDNA, Human Connexin 37/GJA4 (NP_065168)

Mutations in GJA4 have been associated with atherosclerosis and a higher risk of myocardial infarction

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